E-ISSN 2651-3455 (Online) | ISSN 2630-5593 (Print)
Evaluation of HBV and HCV Seroprevalence in Serum Samples of Individuals Diagnosed with Hepatocellular Carcinoma [anatol j fm]
anatol j fm. 2020; 3(2): 116-120 | DOI: 10.5505/anatoljfm.2020.02419

Evaluation of HBV and HCV Seroprevalence in Serum Samples of Individuals Diagnosed with Hepatocellular Carcinoma

Ayfer Bakır1, Mustafa Güney2, Hilal Türkmen Albayrak1, Mehmet Tevfik Yavuz2
1Department of Medical Microbiology, University of Health Sciences, Gulhane Training and Research Hospital, Ankara, Turkey
2Department of Medical Microbiology, University of Health Sciences, Gulhane Faculty of Medicine, Ankara, Turkey

INTRODUCTION: According to the data of the World Health Organization, hepatocellular carcinoma (HCC) is the fifth most common cancer and the second leading cause of cancer-related deaths. This study aimed to investigate the importance of hepatitis B virus (HBV) and hepatitis C virus (HCV) in the viral etiology of HCC. In this study, we evaluated HBsAg and anti-HCV test results in serum samples sent with the diagnosis of HCC to Virology Laboratory.

METHODS: This study was planned as a record-based cross-sectional study. The patients with HCC who were analyzed HBsAg and anti-HCV antibody in serum specimens in Virology Laboratory between October 2016 and December 2018. HBsAg and anti-HCV were tested in serum samples with test parameters chemiluminescent micro-particular enzyme immunoassay method by Architect system.
RESULTS: This study included 44 patients with HCC. The median age of the patients diagnosed with HCC was 64.0 (33.0-88.0) years. Thirty-six (81.8%) of the patients were male, and 8 (18.2%) were female. HBsAg seropositivity was found in 13 (29.5%) patients and anti-HCV seropositivity was found in 2 (4.6%). HBsAg seropositivity was found in 2 (25.0%) of female patients and 11 (30.6%) of male patients (p=0.755). Anti-HCV seropositivity was found in 2 (5.6%) male patients (p=0.666). The highest HBsAg rate was 35.3% in the age group of 50-69 years, and the highest anti-HCV rate was 14.3% in the age group of 70-88 years (p=0.415, p=0.407, respectively).
DISCUSSION AND CONCLUSION: As a result, HBsAg seropositivity was found in 29.5%, and anti-HCV seropositivity was found in 4.6% of the patients diagnosed with HCC. HBV still keeps its importance in the etiology of HCC.

Keywords: Hepatitis B virus, hepatitis C; enzyme immunoassay; hepatocellular carcinoma.

Ayfer Bakır, Mustafa Güney, Hilal Türkmen Albayrak, Mehmet Tevfik Yavuz. Evaluation of HBV and HCV Seroprevalence in Serum Samples of Individuals Diagnosed with Hepatocellular Carcinoma. anatol j fm. 2020; 3(2): 116-120

Corresponding Author: Ayfer Bakır, Türkiye
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