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The Anatolian Journal of Family Medicine Evaluation of Anti-Inflammatory Effect of Pitavastatin with Monocyte Count to HDL Cholesterol Ratio in Patients with Coronary Artery Disease [anatol j fm]
anatol j fm. 2021; 4(1): 13-16 | DOI: 10.5505/anatoljfm.2020.95866

Evaluation of Anti-Inflammatory Effect of Pitavastatin with Monocyte Count to HDL Cholesterol Ratio in Patients with Coronary Artery Disease

Şeyda Günay1, Serhat Çalışkan2
1Department of Cardiology, Bursa Uludag University, Bursa, Turkey
2Department of Cardiology, Istanbul Bahcelievler State Hospital, Istanbul, Turkey

INTRODUCTION: Monocyte count to high-density lipoprotein cholesterol ratio (MHR) was proposed as a novel inflammation marker. Statins have some anti-inflammatory pleiotropic effects as well as lipid-lowering effects. This study aims to examine the effect of lipid-lowering therapy with pitavastatin on MHR in patients with coronary heart disease.
METHODS: This was a descriptive study, single-center study. Hospital registries between October 2018 and April 2019 were retrospectively reviewed. Eligible patients were those who had both stable coronary artery disease and hypercholesterolemia of low-density lipoprotein cholesterol (LDL-C) >100 mg/dL and started to take treatment (pitavastatin, 4 mg/day). Pre-and post-treatment complete blood count values and lipid parameters were evaluated, and MHR was calculated.
RESULTS: This study enrolled 150 patients. Pitavastatin (4 mg/day) was administered throughout median 3.0 (1.0-7.0) months. Mean total cholesterol level declined from 235.2±52.3 mg/dl to 186.9±48.8 mg/dl (p<0.001). Mean triglyceride level declined from 167.2±75.0 mg/dl to 152.8±66.7 mg/dl and mean LDL-C level declined from 153.9±45.0 mg/dl to 109.0±41.2 mg/dl (p=0.020 and p<0.001, respectively). Moreover, pre-treatment MHR declined from 1.4 (0.4-4.0) to post-treatment MHR 1.3 (0.5-3.4) (p=0.263).
DISCUSSION AND CONCLUSION: This study concluded that pitavastatin improved serum lipid levels but did not decrease MHR.

Keywords: Pitavastatin, inflammation, lipids, monocyte, high density lipoprotein

Şeyda Günay, Serhat Çalışkan. Evaluation of Anti-Inflammatory Effect of Pitavastatin with Monocyte Count to HDL Cholesterol Ratio in Patients with Coronary Artery Disease. anatol j fm. 2021; 4(1): 13-16

Corresponding Author: Şeyda Günay, Türkiye
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